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This subtype poses specific challenges in diagnosis and management, including histologic differentiation from surrounding sun-damaged skin with atypical melanocytes, optimizing treatment in anatomically constrained sites where this melanoma subtype tends to occur, and reducing local recurrence rates related to subclinical extensions, all while taking into account quality of life issues and suitability of surgical, topical, and/or radiation therapy in an elderly population

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Plasma levels of GHK naturally decline with age, from roughly 200 ng/mL at age 20 to 80 ng/mL by age 60 (Pickart et al., BioMed Research International, 2015)